Does hydroxychloroquine cause weight gain or weight loss?

Hydroxychloroquine, a medication with diverse applications, has sparked interest regarding its potential effects on body weight.

This comprehensive article explores the relationship between hydroxychloroquine and weight, examining scientific studies, potential mechanisms, and considerations for individuals using this medication.

Understanding Hydroxychloroquine:

  1. Medical Applications:

    • Hydroxychloroquine tablet is known for its use in treating malaria, certain autoimmune diseases like rheumatoid arthritis and lupus, and as a potential treatment in viral infections, including COVID-19.

  2. Mechanism of Action:

    • The exact mechanism by which hydroxychloroquine works is complex and involves various pathways, including interference with lysosomal activity and modulation of the immune response.

Weight Changes Associated with Hydroxychloroquine:

  1. Weight Gain:

    • Some individuals using hydroxychloroquine may experience weight gain as a side effect. The underlying reasons for this are not fully elucidated but may include increased appetite or metabolic changes. buy hydroxychloroquine online at dosepharmacy

  2. Weight Loss:

    • Conversely, weight loss has been reported as a side effect in some cases. Factors contributing to weight loss may include gastrointestinal symptoms like nausea or loss of appetite.

Scientific Studies and Evidence:

  1. Limited and Varied Data:

    • Scientific evidence regarding the direct impact of hydroxychloroquine on weight is limited and often inconclusive. Studies exploring this relationship are scarce, and existing data may be confounded by the diverse applications of the medication.

  2. Influence on Metabolism:

    • Hydroxychloroquine’s influence on metabolism remains an area of investigation. Some studies suggest a potential role in improving insulin sensitivity, but the overall impact on body weight is not well-established.

Considerations for Individuals:

  1. Individual Responses:

    • Responses to hydroxychloroquine can vary widely among individuals. Factors such as underlying health conditions, dosage, and duration of use may contribute to the diversity of reported effects on weight.

  2. Monitoring and Consultation:

    • Individuals prescribed hydroxychloroquine should be monitored for changes in weight, and any concerns should be discussed with healthcare providers. Regular check-ups can help address potential side effects promptly.

Balancing Risks and Benefits:

  1. Clinical Decision-Making:

    • The decision to use hydroxychloroquine should be based on a thorough evaluation of the individual’s medical condition and a careful consideration of potential risks and benefits.

  2. Potential Side Effects:

    • Besides weight-related considerations, hydroxychloroquine may be associated with other side effects, including ocular issues, cardiovascular effects, and dermatological reactions. These aspects should be discussed with healthcare providers.

  3. Factors Influencing the Onset of Accutane’s Effects: In addition to the individual factors mentioned previously, here are some additional factors that can influence the onset of Accutane’s effects:

    • The type of acne: Accutane is most effective in treating inflammatory acne, which includes pustules, papules, and nodules. It may not be as effective for non-inflammatory acne, such as blackheads and whiteheads.

    • The dosage of Accutane: Higher dosages of Accutane may lead to faster results, but they also increase the risk of side effects. Therefore, it is important to start with a lower dosage and gradually increase it as needed under the supervision of a healthcare provider.

    • The use of other medications: Some medications, such as corticosteroids and oral contraceptives, can interfere with the effectiveness of Accutane. It is important to inform your healthcare provider about all the medications you are taking before starting Accutane treatment.

  4. Managing Expectations During Accutane Treatment:

    • Initial worsening: As mentioned earlier, some individuals may experience an initial worsening of acne during the first few weeks of Accutane treatment. This is temporary and usually subsides within a few weeks.

    • Dry skin and lips: Accutane can cause dryness of the skin and lips. This is a common side effect and can be managed with the use of moisturizers and lip balms.

    • Flare-ups after treatment: While Accutane can effectively clear acne, some individuals may experience breakouts again after completing treatment. This is known as acne recurrence. If this occurs, it may be necessary to repeat Accutane treatment.

  5. Importance of Regular Monitoring: Regular monitoring by a healthcare provider is crucial during Accutane treatment. This allows for:

    • Assessing treatment progress: Regular check-ups help assess the effectiveness of the medication and identify any potential side effects.

    • Adjusting the dosage: The dosage may need to be adjusted based on the patient’s response to treatment and the severity of side effects.

    • Addressing concerns: Patients can discuss any concerns they may have about the treatment or potential side effects.

Conclusion: Navigating Hydroxychloroquine and Weight Dynamics

Hydroxychloroquine’s impact on weight remains an area requiring further exploration. While weight gain and loss have been reported as side effects, the evidence is not robust, and individual responses vary. As with any medication, the decision to use hydroxychloroquine should involve thoughtful discussion with healthcare providers, emphasizing personalized considerations and a balanced assessment of potential risks and benefits.



  1. Chen, C., et al. (2019). Hydroxychloroquine reduces risk of incident diabetes mellitus in lupus patients in a dose-dependent manner: a population-based cohort study. Rheumatology, 58(12), 2167–2175.

  2. Tleyjeh, I. M., et al. (2020). Association of Hydroxychloroquine with Cardiovascular Mortality in COVID-19 Patients. J Am Coll Cardiol, 76(5), 569–581.

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