IgA Class Switching
The adaptive immune response includes T cell-independent (TI) responses, which develop without the assistance of T-cell signals. Mucosal immunity is greatly influenced by this T-cell-independent IgA class switching, which serves as an essential first line of defense against numerous infections. Studies of the gut mucosa, which is a rich source of B cells that produce IgA, have provided us with a great deal of information on this process. Maintaining gut homeostasis is largely dependent on commensal bacteria’s expansion of TI IgA responses. When mucosal B cells interact with the microbiota, they begin to produce IgA instead of IgM. This is known as TI-commensal-dependent IgA (TI-CD-IgA), which is a common TI pathway.
